Nelumbo nucifera herb, seeds, plant, extract

Nelumbo nucifera Gaertn. (Nymphaceae) has been used for various medicinal purposes by Chinese herbalists. Flavonoids in the leaves of Nelumbo nucifera Gaertn (lotus leaves) have many pharmacological activities. Some of these flavonoids include hyperin, isoquercetin and astragalin.

Nelumbo nucifera seed extract sedative effect
Effects of extracts and neferine from the embryo of Nelumbo nucifera seeds on the central nervous system.
Phytomedicine. 2008 Dec; Sugimoto Y, Furutani S, Itoh A, Tanahashi T, Nakajima H, Oshiro H, Sun S, Yamada J. Laboratory of Pharmacology, Department of Clinical Pharmacy, Yokohama College of Pharmacy, Totsuka-ku, Yokohama 245-0066, Japan.
The effects of embryos of the seeds of Nelumbo nucifera on the central nervous system were studied in mice. MeOH extracts of embryos of Nelumbo nucifera seeds significantly inhibited locomotor activity in mice. Our results suggest that neferine has several central effects and that neferine may participate in the efficacy of the sedative effects of embryos of the seeds of Nelumbo nucifera. The mechanisms of the sedative effects of neferine are not similar to those of diazepam.

Nelumbo nucifera herb research studies, effect on corpus cavernosum
Effects of plant extract neferine on cyclic adenosine monophosphate and cyclic guanosine monophosphate levels in rabbit corpus cavernosum in vitro.
Asian J Androl. 2008 March. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
To further investigate the relaxation mechanism of neferine, a bis-benzylisoquinoline alkaloid extracted (isolated) from the green seed embryo of Nelumbo nucifera Gaertn in China, on rabbit corpus cavernosum tissue in vitro. Neferine from Nelumbo nucifera, with its relaxation mechanism, can enhance the concentration of cAMP in rabbit corpus cavernosum tissue, probably by inhibiting phosphodiesterase activity.

Nelumbo leaf extract and fat cells
Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice.
Planta Med. 2007 October. Ohkoshi E, Miyazaki H, Shindo K, Watanabe H, Yoshida A, Yajima H. KIRIN Brewery Co., Ltd., Central Laboratories for Frontier Technology, Kanagawa, Japan.
Nelumbo nucifera leaves are known for diuretic and astringent properties, and are used to treat obesity. During our search for a plant-derived anti-obesity agent from natural products, we have found that a 50% ethanol extract prepared from the leaves of Nelumbo nucifera stimulated lipolysis in the white adipose tissue of mice and that the beta-adrenergic receptor pathway was involved. In subsequent experiments, dietary supplementation of Nelumbo nucifera resulted in a significant suppression of body weight gain in A/J mice fed a high-fat diet. Our results indicate that the effects of Nelumbo nucifera in preventing diet-induced obesity appear to be due to various flavonoids and that the activation of beta-AR pathway was involved, at least in part.

A new lipid and other constituents from the rhizomes of Nelumbo nucifera.
J Asian Nat Prod Res. 2009 Jul; Chaudhuri PK, Singh D. Phytochemistry Division, Central Institute of Medicinal and Aromatic Plants, Lucknow, India.
A new ursane triterpenoid ester, urs-12-en-3beta-O-9E,12E-octadecadienoate, was identified from the rhizomes of Nelumbo nucifera by spectral and chemical analyses along with the isolation of seven known compounds: palmitic acid, linoleic acid, 9E,12E,15E-octadecatrienoic acid, alpha-amyrin, beta-sitosterol, betulinic acid, and beta-sitosterol-3-O-glucoside.

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